Generalized lymphadenopathy (e.g., cervical, supraclavicular, axillary, and inguinal lymphadenopathy; hepatomegaly; splenomeg ly)

—      Infection
Tuberculosis
Secondary syphilis

—      Mononucleosis
HIV/AIDS
Kawasaki’s syndrome

—      Typhoid fever

—      Hypersensitivity reactions

—      Serum sickness

—      Drugs (e.g., hydantoin, phenytoin, hydralazine, allopurinol, primidone)

—      Lymphoma

—      Leukemia

—      Connective tissue disorders (e.g., SLE, rheumatoid arthritis)

—      Sarcoidosis

—      Metastatic cancer [especially with left supraclavicular lymphadenopathy (Virchow’s node) associated with abdominal malignancies, including stomach, pancreas, gallbladder, testis/ovary, kidney, and prostate cancers]

—      Endocrine disorders (e.g., hyperthyroidism, hypoadrenalism)

—      Amyloidosis

—      Castleman’s syndrome (angiofollicular lymph node hyperplasia)

—      Kikuchi’s disease

—      Localized lymphadenopathy

—      Reactive hyperplasia, local inflammation (e.g., dermatitis, vaccination, trauma)

—      Infection
Viral: Mononucleosis, CMV, HIV, rubella, mumps

—      Bacterial: Streptococcus, tuberculosis, salmonella, cat-scratch disease (due to Bartonella henselae); gonorrhea, Chlamydia, and other sexually transmitted diseases (inguinal)

—      Parasitic: Malaria, toxoplasmosis

—      Fungal: Histoplasmosis, coccidioidomycosis

—      Lymphoma or metastatic disease (e.g. head and neck squamous cell cancer leads to cervical lymphadenopathy)

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